מאגר פרסומים

רשימת פרסומים - מחקרים ד"ר לירון קוגן

מחקר

מחקר קליני ומעבדתי הם בעיני כלים להפוך לרופא טוב יותר. מחקר קליני משמש בראש ובראשונה לצורך בקרה פנימית. ההבנה שלנו, לגבי דברים שעשינו בעבר ואנו עושים כעת עבור המטופלות שלנו, מאפשרת לנו להשתפר.

מחקר מעבדתי יחד עם הבנה עמוקה של התהליכים הביולוגיים מאחורי התופעות הקליניות , בעידן של רפואה מוכוונת מטרה, מאפשר לי לתפור את חליפת הטיפול המתאימה ביותר למטופלות. 

בשנים האחרונות, עיקר המחקר שלי התמקד ב:

1. סמנים גנטיים בסרטן השחלה ובסרטן רירית הרחם,

   תוך מיקוד בגנים הקשורים לתיקון DNA כמו BRCA (קבוצת ה-HRD).

2. השמנה וסרטן רירית הרחם.

3. ניתוחי רובוט בממאירויות גינקולוגיות. 

4. בלוטות זקיף בסרטן רירית הרחם. 

לרשימת הפרסומים:

פתחי את הכותרת ויוצג לך המחקר- פרסום. 

להלן רשימת הפרסומים שלי (עדכנית לדצמבר 2019):

מחקרים - 1-10


1: Targeted sequencing of histologically defined serous endometrial cancer
reflects prognosis and correlates with preoperative biopsy
Gynecol Oncol Rep 2019. PubMed PMID: 31867434. PubMed Central
PMCID: PMC6906727.

2: Biguanides in combination with olaparib limits tumorigenesis of drug-
resistant ovarian cancer cells through inhibition of Snail
Cancer Med 2019. PubMed PMID: 31863638.
3: Incorporating robotic surgery into the management of ovarian cancer after
neoadjuvant chemotherapy
Int J Gynecol Cancer 2019. PubMed PMID: 31601648.
4: Outcome-Related Differences in Gene Expression Profiles of High-Grade Serous
Ovarian Cancers Following Neoadjuvant Chemotherapy Mol Cancer Res 2019. PubMed PMID: 31530633.
5: Preferred way of delivery of the impacted fetal head in cesarean sections
during second stage of labor J Obstet Gynaecol Res 2019. PubMed PMID: 31502321.
6: Risk factors for lymph nodes involvement in obese women with endometrial
carcinomas Gynecol Oncol 2019. PubMed PMID: 31349997.
7: Triple tracer (blue dye, indocyanine green, and Tc99) compared to double
tracer (indocyanine green and Tc99) for sentinel lymph node detection in endometrial cancer: a prospective study with random assignment Int J Gynecol Cancer 2019. PubMed PMID: 31320490.
8: Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional
BRCA1BMC Cancer 2019. PubMed PMID: 30630446. PubMed Central PMCID: PMC6327434.
9: Oncologic and Surgical Outcomes of Robotic Versus Open Radical Hysterectomy
for Cervical Cancer J Obstet Gynaecol Can 2019. PubMed PMID: 30529223.
10: Risk of Thromboembolic Disease With Cost Estimates in Patients Undergoing
Robotic Assisted Surgery for Endometrial Cancer and Review of the Literature
J Obstet Gynaecol Can 2018 - Review. PubMed PMID: 30262383.




מחקרים 11-20


11: Impact of lower uterine segment involvement in type II endometrial cancer
and the unique mutational profile of serous tumors Gynecol Oncol Rep 2018.
PubMed PMID: 29915797. PubMed Central
PMCID: PMC6003406.
12: Distinct homologous recombination gene expression profiles after neoadjuvant
chemotherapy associated with clinical outcome in patients with ovarian cancer
Gynecol Oncol 2018. PubMed PMID: 29395310.
13: Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines
to PARP inhibitors BMC Cancer 2017. PubMed PMID: 28886696. PubMed Central PMCID: PMC5591502.
14: Dose dense carboplatin paclitaxel improves progression free survival in
patients with endometrial cancer Gynecol Oncol 2017. PubMed PMID: 28735629.
15: Operative hysteroscopy for treatment of intrauterine pathologies does not
interfere with later endometrial development in patients undergoing in vitro
fertilization Arch Gynecol Obstet 2016. PubMed PMID: 26676830.
16: microRNAs and Endometrial Pathophysiology
Adv Exp Med Biol 2015. PubMed PMID: 26662990.
17: Very High Intrapartum Fever in Term Pregnancies and Adverse Obstetric and
Neonatal Outcomes Neonatology 2016. PubMed PMID: 26536344.
18: Influence of late-age births on maternal longevity
Ann Epidemiol 2015. PubMed PMID: 25976022.
19: Emerging roles of microRNA in the embryo-endometrium cross talk
Semin Reprod Med 2014 - Review. PubMed PMID: 24959822.
20: The association of maternal intrapartum subfebrile temperature and adverse
obstetric and neonatal outcomes Paediatr Perinat Epidemiol 2014 - Clinical Trial. PubMed PMID: 24118104.




מחקרים 21-29


21: Leukocyte blood count during early puerperium and its relation to puerperal
infection† J Matern Fetal Neonatal Med 2014.
PubMed PMID: 23617780.
22: Radical trachelectomy: a fertility-sparing option for early invasive
cervical cancer Isr Med Assoc J 2012 - Review. PubMed PMID: 22799068.
23: Trial of labor after two cesarean sections: the policy in Israel and four
years experience Harefuah 2011 - Review. PubMed PMID: 22428209.
24: Robotic-assisted gynecological surgeries: a series of the first 14 cases
Harefuah 2011. PubMed PMID: 22026054.
25: Selected clinical characteristics of Israeli Jewish women with squamous cell
carcinoma of the uterine cervix: a population-based study Isr Med Assoc J 2011. PubMed PMID: 21443032.
26: Fertility in women after surgical treatment of nonepithelial ovarian tumors Fertil Steril 2010. PubMed PMID: 20673891.
27: A population-based study of selected demographic characteristics of Israeli-
Jewish women with cervical squamous cell carcinoma Arch Gynecol Obstet 2011. PubMed PMID: 20623130.
28: Selected demographic characteristics of Israeli Jewish women with high-grade
cervical intraepithelial neoplasia (CIN3): a population-based study Arch Gynecol Obstet 2011. PubMed PMID: 20191281.
29: Incidence trends of cervical adenocarcinoma in Israeli Jewish women. A
population-based study Acta Obstet Gynecol Scand 2009. PubMed PMID: 19172425.